Nerium International is the first company with the exclusive capability to harness the power of the Nerium oleander plant in its skincare products. Nerium International is the first company with the exclusive capability to harness the power of the Nerium oleander plant in its skincare products. The product line addresses multiple concerns at once, including: wrinkles, discoloration, and texture. Nerium controls this main active ingredient from seed to bottle, making the Nerium skincare line both high-impact and innovative. This is the Nerium Difference.